Resident Evil: Code Veronica X begins as Claire Redfield leaves Raccoon City for the European headquarters of the Umbrella Corporation to search for her brother Chris and solve the mystery surrounding Umbrella Corporation's dreaded biotoxins. She is captured during her investigation and sent to a prison on a desolate island.

In Resident Evil: Code Veronica X, players control Claire at the beginning of the game, and later assume the role of Chris Redfield in their efforts to halt Umbrella's devious plans. One of the many features that make Code Veronica X different from previous Resident Evil games is the Real World System (RWS). Now when Claire affects changes to her environment (opening doors, solving puzzles, storing items), those changes remain while you play the second half of the game as Chris.

Resident Evil: Code Veronica X contains never-before-seen footage that focuses on battles between Chris and the enigmatic Wesker, and sheds new insight into the ominous Resident Evil story line. To her horror, Claire discovers Umbrella Corporation's insidious activities are not isolated to the remote Midwestern city. Flesh-eating zombies, horrific beasts, and even stranger mutations have spread on a global scale. Just how far does this twisted conspiracy extend? Nope.